Top 3 Saypha Fillers Practitioners Choose

While the Saypha filler line is not a massive catalogue with dozens of variations, Croma-Pharma ensured that it covers the entire spectrum of facial rejuvenation needs. Although Saypha doesn’t offer the widest range of products, there are still top Saypha fillers among them that practitioners use most often in 2026. 

Saypha’s History

Croma-Pharma, the manufacturer behind Saypha, got its start in 1976 when pharmacists Gerhard and Karin Prinz began distributing medicines that were not yet registered in Austria. What began as a single family pharmacy near Vienna grew into a manufacturer of hyaluronic acid (HA) syringes. The company started delving into dermatological aesthetics in 2009, and its HA filler portfolio built a strong reputation across Europe. 

Today, Croma-Pharma runs a modern production facility in Leobendorf, Austria. The facility was completed in 2017 and built around one of the most advanced automatic syringe filling systems available. The company employs roughly 400 people and ships its products to more than 80 countries. 

Saypha Product Composition

Every product in the line starts with hyaluronic acid of non-animal origin. The HA is cross-linked with BDDE (1,4-butanediol diglycidyl ether) to slow the gel’s natural breakdown in tissue. Saypha Volume and Saypha Volume Lidocaine both carry 25 mg/mL of HA. Saypha Volume Plus Lidocaine steps up to 26 mg/mL for added lift in more demanding cases. All three gels are formulated at a buffered pH of 7 for tissue compatibility. Two of the three also include 0.3% lidocaine to reduce discomfort during injection.

S.M.A.R.T. Technology

The line’s cross-linking process is built on S.M.A.R.T. technology, short for Supreme Monophasic and Reticulated Technology. “Monophasic” describes a single-phase gel with no separate particles floating in a carrier fluid. That structure allows for a smooth injection and even distribution under the skin. 

“Reticulated” refers to how tightly the HA chains are cross-linked and interlocked during manufacturing. This denser structure resists enzymatic breakdown for longer, so patients see much more durable results from a volumizing filler. Combined together, these two properties give Saypha gels their blend of moldability during injection and firm, lasting structure once they settle into tissue.

Top 3 Popular Saypha Fillers

Saypha Volume

Saypha Volume is the base formula in the line. It corrects deep wrinkles and folds, cutaneous depressions, and lost facial volume. It contains no lidocaine. Some practitioners prefer that for patients with a lidocaine sensitivity, or for cases where a topical or local anesthetic is already part of the protocol. The thick gel goes into the deep dermis or subcutis, most often in the cheeks and midface. There, it restores contour and lift without a heavy, overfilled look.

SAYPHA®

SAYPHA VOLUME 1ML

♡

Hyaluronic Acid

$68.00
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Add to cart

Discount structure

• 1 - 4 packs - $68.00 each
• 5 - 9 packs - $65.96 each
• 10 - 19 packs - $64.60 each
• 20 - 29 packs - $62.56 each
• 30+ packs - $61.20 each

Saypha Volume Lidocaine

Saypha Volume Lidocaine uses the same 25 mg/mL HA formula as Saypha Volume. It adds 0.3% lidocaine for patient comfort. The indication stays the same: midface and cheek volume loss. The built-in anesthetic makes it a practical choice for practices that want to skip a separate numbing step. Patients often report a more comfortable visit while getting the same structural correction as the lidocaine-free version.

SAYPHA®

SAYPHA VOLUME LIDOCAINE 1ML

♡

Hyaluronic Acid + Lidocaine

$69.00
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Add to cart

Discount structure

• 1 - 4 packs - $69.00 each
• 5 - 9 packs - $66.93 each
• 10 - 19 packs - $65.55 each
• 20 - 29 packs - $63.48 each
• 30+ packs - $62.10 each

Saypha Volume Plus Lidocaine

Saypha Volume Plus Lidocaine is the strongest option in the collection. It is formulated at 26 mg/mL HA with 0.3% lidocaine. It targets deep and severe facial wrinkles and significant volume loss. It also covers jawline and chin contouring, in addition to the cheeks and midface. Besides structural correction, it makes the skin more radiant, a subtle but noticeable effect that many patients seek. Its higher HA concentration often makes it the filler of choice for patients who need a more noticeable lift in a single session.

SAYPHA®

SAYPHA VOLUME PLUS LIDOCAINE 1ML

♡

Hyaluronic Acid + Lidocaine

$83.00
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Add to cart

Discount structure

• 1 - 4 packs - $83.00 each
• 5 - 9 packs - $80.51 each
• 10 - 19 packs - $78.85 each
• 20 - 29 packs - $76.36 each
• 30+ packs - $74.70 each

Clinical Evidence Behind Saypha Fillers

The Volume Plus Lidocaine formula has been studied for midface augmentation in the PRIMAvera clinical study. This multicenter, open-label trial followed 91 patients with moderate to severe midface volume deficit. Investigators and patients rated aesthetic improvement on the Global Aesthetic Improvement Scale through week 52. Roughly half of patients still reported feeling very satisfied at that final follow-up. 

The median time before the treatment effect wore off was 386 days, close to thirteen months. Separate patient satisfaction data for the line show strong numbers across the board. Ninety percent of patients were satisfied one month after treatment. Ninety-three percent were still satisfied at 36 weeks. And 98% said they would recommend the filler to others. For a practice deciding whether to add a new HA line to its shelves, that long-term data carries real weight.

Choosing the Right Saypha Filler for Each Patient

Stocking all three formulas gives a practice room to match the product to the patient, instead of adjusting the treatment plan around whatever happens to be on hand. A few starting points make that decision easier during a consultation:

• Reach for Saypha Volume when a patient has a known lidocaine sensitivity, or when a separate anesthetic is already planned for the visit.
• Choose Saypha Volume Lidocaine for standard cheek and midface volume loss, where comfort during injection is a priority.
• Move up to Saypha Volume Plus Lidocaine for severe volume deficits, or when jawline and chin contouring are part of the treatment goal.
• Factor in a patient’s downtime tolerance, since the thicker Volume Plus formula may call for slightly more careful massage and aftercare instructions.

None of these questions take more than a few minutes to work through. They help set realistic expectations before the needle ever touches the skin.

Best-Selling Saypha Fillers Cost

Below are the current wholesale prices for the top Saypha fillers available through Cosmo Direct Supply. Ordering directly from a dedicated aesthetic medicine supplier keeps costs predictable. It also gives a practice access to genuine, manufacturer-sourced product.

Volume discounts are available on all three products for practices ordering in bulk. Cosmo Direct Supply ships most orders the next business day. Stocking the full lineup from a trusted Saypha wholesaler means you are always confident in the quality of the products you’re administering to your patients.

Top Saypha Fillers and Other Products

Saypha is a filler line practitioners and clients have come to trust over the years of seeing real, lasting results. While the top Saypha fillers are an obvious choice, get acquainted with the rest of the range to see everything they can offer and maybe find something you’ve been looking for. 

The Most Popular Saypha Fillers FAQ