The impact of Restylane on the aesthetic medicine market is undeniable. Pioneering the field of hyaluronic acid dermal fillers, it set new standards for injectable treatments. The brand continues to lead the market with the top 5 Restylane fillers of 2025.
The Story Behind Restylane
Restylane introduced their first non-animal stabilized hyaluronic acid (HA) filler in 1996, reshaping the way we think about beauty procedures. Galderma’s scientists in Uppsala, Sweden, have made a breakthrough with a biocompatible substance, replacing animal-based options that came with more risks and inconvenience for the patients.
“The hyaluronic acid molecule is fantastic,” says Per Winlöf, Galderma’s Chief Design Expert in Uppsala. “You can put it into the body and the body will accept it. So, what we did was to develop a method to make that material insoluble.”
After successful initial clinical trials, the laboratory focused on scaling up to keep up with the growing demand. Now, the team supplies approximately 9 million units a year without compromising product quality. Over the past 30 years, Restylane has continued to grow, introducing new fillers with the same dedication to innovation, safety, and efficacy. An impressive 65 million treatments worldwide, FDA approval in 2003, and Health Canada certification are the best evidence of the brand’s success.
Restylane Product Composition
Restylane fillers are famously made using non-animal stabilized hyaluronic acid as a base for their fillers. It imitates the natural HA – incredibly biocompatible and highly unlikely to cause an adverse immune reaction. Chemically crosslinked with BDDE (1,4-butanediol diglycidyl ether), it’s resistant to rapid breakdown and offers long-lasting effects. Lidocaine added to the formulation is important for the client’s comfort during the injection. It also minimizes the minor e
Restylane Technology
NASHA and OBT are the two complementary technologies that made the top Restylane dermal fillers as popular as they are. NASHA undergoes minimal chemical crosslinking for ultimate consistency and biocompatibility. Besides a lower risk of adverse reactions, it also offers a more regular gel firmness. It gives you more control when performing sculpting or lifting treatments, ensuring client satisfaction. The gel is on the firmer side, with a high G, for a more pronounced effect.
The OBT, also known as XpresHAn technology, takes a different approach. All about adaptability, OBT-based solutions are perfect for areas with high mobility. With higher flexibility and lower immediate firmness, they are a better fit for zones like lips and cheeks. Patients note satisfactory results along with movement freedom and a natural feel of facial expressions.
These two advanced technologies are what Restylane’s scientists used to create a large selection of fillers that precisely target different aesthetic concerns with higher efficacy. You can choose the exact product that works not just for a general indication, but for the specific movement, texture, and needs of each treatment area.
Top 5 Restylane Dermal Fillers
Restylane Kysse
Restylane Kysse is undoubtedly one of the top Restylane fillers out of the whole product line. Its effectiveness for lip treatments has been proven and tested countless times. Practitioners find it easy to use, and patients love the results of a natural-looking enhancement.
Results are visible for up to 12 months, it’s durable yet flexible – the filler doesn’t restrict movements and the patients can show the full range of emotion, the way they’re used to. The filler also hydrates the lips and improves elasticity, enhancing the appearance along with texture and feel.
Restylane Lyft
This option is most suitable for midface augmentation and deep wrinkle correction. The formulation is firmer, able to significantly lift the tissue and restore volume in cheeks, jawline area, and hands. Restylane Lyft has larger particle size needed to address nasolabial folds in the most effective way.
Used to reshape the face and correct contours, the solution restores the youthful appearance many clients seek. The effects show for approximately 6-9 months, depending on individual characteristics and the patient’s habits.
Restylane Eyelight
The filler hydrates the sensitive under-eye area and smoothes out the fine line, but the list of effects doesn’t end there. This solution also brightens dark circles and restores volume – both a source of insecurity for many. Eyelight’s gentle formulation delivers effects that don’t fade away quickly either, visible for up to 12 months.
Restylane Defyne
With a focus on cheeks, laugh lines, and nasolabial folds, this product is known for its ability to correct even severely deep folds and wrinkles. The formulation offers this effect without stiffness or restricted movements. Apart from wrinkle correction, it can be used for facial contouring and volume restoration in areas like cheeks and chin. Just like many Restylane fillers do, this solution provides long-lasting results too, the effects present for up to 12 months.
Restylane Refyne
Refyne is a versatile formulation practitioners often choose for moderate folds and wrinkles, especially around the nose and mouth. In addition, the formulation is flexible enough to be used for lip enhancement. Working on skin elasticity, the filler makes the skin look and feel smoother and younger. This option also shows durable effects with longevity of up to 12 months.
Best Restylane Dermal Fillers 2025 Cost
Find the prices of top Restylane fillers in the table below. Besides the mentioned prices, you can buy Restylane online wholesale at Cosmo Direct Supply and significantly cut your expenses.
| Product | Cost |
|---|---|
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$114.37 |
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$138.87 |
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$122.54 |
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$138.87 |
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$138.87 |
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$138.87 |
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$138.87 |
We are proud that many medical professionals worldwide choose to stock up at Cosmo Direct Supply. A trusted aesthetic medicine supplier, we offer original products straight from manufacturers at the most competitive wholesale prices.
Conclusion
In 2025, the top Restylane dermal fillers have long since solidified their place in aesthetic medicine as essential everyday instruments for many clinics, medispas, and practitioners globally. These reliable, safe, effective, and evidence-backed solutions help you build a foundation of patient trust – ultimately turning first-time clients into loyal, long-term patients.
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What are the top Restylane dermal fillers in 2025?
The top Restylane fillers of 2025 include options like Restylane Kysse, Lyft, Defyne, Refyne, and Eyelight. These target different treatment zones and form a comprehensive portfolio that allows for highly personalized treatment plans.
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Which Restylane filler is best for cheeks?
Restylane Lyft and Defyne and the two leading options when it comes to cheek area correction. The mid-face tends to descend with age, leading to the cheeks flattening and nasolabial folds deepening. Restylane Lyft especially has one of the highest G levels in the entire product line – it’s a firm, cohesive gel that can support tissue, project the cheek contour upward and outward, and provide a significant lifting effect on the entire midface. -
Which Restylane filler lasts the longest?
One of the top Restylane fillers in terms of durability is Restylane Volyme. Although the general duration period is up to 12 months, some patients experience its effects for up to 18 months. The exact time frame comes down to the patient’s metabolism rate, skin type, and lifestyle habits like proper hydration, a balanced diet, and avoiding excessive sun exposure.